Main Results A total of 15 studies (4 comparative retrospective, 8 retrospective, and 3 prospective) including 470 patients (264 LGEA) were identified 344 (73%) patients underwent CI, 99 (21%) GPU, and 27 (6%) JI. Data were computed by Comprehensive Meta-Analysis software (Version 2.2.064). Among long-term gastrointestinal outcomes were dysphagia, reflux, and dumping among long-term respiratory outcomes were recurrent pneumonia and recurrent aspiration leading to chronic lung disease. The focus was on postoperative survival rate, morbidity (gastrointestinal complications such as anastomotic stenosis/leakage and respiratory complications such as pneumothorax, pneumonia, and atelectasis), and long-term follow-up when available. Methods Review of the English-language literature published in the past 5 years about esophageal replacement in children was done. The aim of this article was to perform a meta-analysis comparing the most widely used techniques for esophageal replacement in children: jejunal interposition (JI), colon interposition (CI), and gastric pull-up (GPU). Aim There is still no consensus about the optimal surgical approach for esophageal replacement in the case of long-gap esophageal atresia (LGEA) or extensive corrosive strictures.
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